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自1981年12月17日到1991年9月10日,在意大利佩萨罗连续对470例病人进行了HLA相合供4者的骨髓移植,移植后1年生存率和无病生存率分别为82%和74%。自1981年起采用多种不同的方法预防急性移植物抗宿主病,1983年1月我们采用的预处理包括马利兰14mg/kg、环磷酰胺200mg/kg和自-2天起单用环胞霉素。这个预处理方案6,其毒副作用小,并可使排斥率由12%降至6%。自1983年1月到1989年3月,采用方案6连续为172例病人进行了移植。单方面和多方面的调
From December 17, 1981 to September 10, 1991, 470 patients were consecutively HLA-matched for four bone marrow transplants in Pesaro, Italy. The 1-year survival and disease-free survival rates after transplantation were 82 % And 74%. A variety of different approaches have been used to prevent acute graft-versus-host disease since 1981. Our January 1983 pretreatment included mari- lan 14 mg / kg, cyclophosphamide 200 mg / kg and cyclosporine Prime This pretreatment program 6 has low toxic side effects and reduces the rejection rate from 12% to 6%. From January 1983 to March 1989, a total of 172 consecutive patients underwent transplanted using protocol 6. Unilateral and multi-pronged approach