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帕金森病(PD)是老年人常见的神经退行性疾病,发病机制至今不明。最近研究发现,α-突触核蛋白与PD发病密切相关。α-突触核蛋白在聚集过程中形成的寡聚体中间构象细胞毒性很强,可能对PD发病过程起重要作用;多种遗传学与细胞学因素影响这种聚集状态的转换过程,在一定程度上反映了PD发生的遗传学与细胞学机制。
Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, the pathogenesis is unknown. Recent studies found that α-synuclein is closely related to the pathogenesis of PD. α-synuclein in the process of aggregation of the oligomer intermediate conformation cytotoxic strong, may play an important role in the pathogenesis of PD; a variety of genetic and cytological factors affect the aggregation state of the conversion process, in a certain The extent reflects the genetics and cytology of PD.