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动物研究表明许多肿瘤对药物或放射敏感,剂量反应曲线常常是陡峭的,适当逐渐加大剂量。可提高对肿瘤细胞的杀灭。因为骨髓中毒是许多细胞毒药物剂量受限的因素,因而用超致死剂量的骨髓破坏疗法,随后给予骨髓移植作血液学解救,对其肿瘤对化疗或放疗敏感的病人,有可能提供治愈的机会。骨髓移植(BMT)治疗恶性疾病的理论基础是基于下述3个原理:①疾病通过很强烈的治疗是可治愈的,②用骨髓破坏疗法引起全血细胞减少期间,若提供支持疗法,能够保持病人存活;
Animal studies have shown that many tumors are sensitive to drugs or radiation and the dose response curve is often steep, with appropriate dose escalation. Can increase the killing of tumor cells. Because bone marrow poisoning is a limiting factor in the dosage of many cytotoxic drugs, hematologic rescue with a sublethal dose of bone marrow followed by bone marrow transplantation may offer a cure for patients whose tumors are sensitive to chemotherapy or radiotherapy . The rationale for bone marrow transplantation (BMT) in the treatment of malignant disease is based on the following three principles: (1) the disease is curable through very intense treatment; (2) during the period of pancytopenia caused by bone marrow destroying therapies, Survive