论文部分内容阅读
年龄相关性黄斑变性是老年人群中主要的不可逆致盲眼病,其主要致病因素包括年龄增长、遗传变异和生活方式等,但具体致病机制尚未完全阐明。蛋白质组学技术作为近年来新兴的研究手段已经逐步应用于眼科领域。目前已经有大量研究对该疾病患者的血液、泪液、房水、玻璃体液、视网膜和脉络膜、玻璃疣以及视网膜色素上皮细胞标本进行了蛋白质组学分析来筛选疾病的生物标志物并探究疾病相关机制。这些研究结果不仅能够帮助我们对疾病作出更加准确的诊断,还能在治疗靶点的选择以及预后判断中起到指导作用。“,”Age-related macular degeneration (AMD) is the mainirreversible blinding eye disease in the elderly.Its main pathogenic factors include age, genetic variation and lifestyle, but the specific pathogenesis has not been fully elucidated.As an emerging research method, proteomics technology has been gradually applied in the field of ophthalmology in recent years.A large number of studies about proteomic analysis of blood, tears, aqueous humor, vitreous humor, retina and choroid, drusen and RPE cell samples from AMD patients have been carried out to screen AMD biomarkers and explore the mechanism of AMD.These results can not only help us to make a more accurate diagnosis of AMD, but also play a guiding role in the selection of treatment targets and prognosis.