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应用部分脾栓塞术(PSE)治疗难治性原发性血小板减少性紫癜27例,血栓性血小板减少性紫癜1例;难治性再生障碍性贫血2例;Evan’s 综合症2例;系统性红斑狼疮合并血小板减少性紫癜2例;继发性脾亢3例.获完全缓解者24例(64.9%);部分缓解者8例(21.6%),总有效率为86.S%.24例获完全缓解者18例追踪1年,6例复发,复发率为33.3%.与25例切脾对照组及文献报道比较,差异无显著性(P>0.05).本文对 PSE 术后外周血小板的变化进行讨论,并与脾切除作了对比。本文还对血小板破坏场、栓塞范围和方法等影响疗效的因素进行了探讨.作者认为 PSE 术可作为脾切除的替代术.
Partial splenic embolization (PSE) in the treatment of refractory primary thrombocytopenic purpura in 27 cases, thrombotic thrombocytopenic purpura in 1 case; refractory aplastic anemia in 2 cases; Evan’s syndrome in 2 cases; systemic erythema 2 cases of lupus combined with thrombocytopenic purpura; 3 cases of secondary hypersplenism, 24 cases (64.9%) with complete remission, 8 cases (21.6%) with partial remission, the total effective rate was 86% 18 cases of complete remission were followed up for 1 year and 6 cases relapsed with a recurrence rate of 33.3% .There was no significant difference between 25 cases of splenectomy and the control group (P> 0.05) .This study analyzed the changes of peripheral platelets The discussion was compared with splenectomy. This article also discusses the factors that affect the efficacy of platelet destruction site, embolization range and methods, etc. The authors believe that PSE can be used as an alternative to splenectomy.