卵巢恶性肿瘤是女性生殖器常见的三大恶性肿瘤之一,死亡率居妇科恶性肿瘤首位。研究发现约5%~10%的卵巢上皮癌具有遗传异常,它的发生主要与BRCA1基因突变相关。现将BRCA1与卵巢癌的发生、发展、治疗以及预后的关系综述如下。1 BRCA1基因的结构与功能BRCA1基因是抑癌基因,它定位 Ovarian cancer is one of the three most common malignant tumors in female genitalia, with the highest mortality rate among gynecological malignancies. Study found that about 5% to 10% of epithelial ovarian cancer with genetic abnormalities, its occurrence is mainly associated with BRCA1 gene mutations. Now the relationship between BRCA1 and the occurrence, development, treatment and prognosis of ovarian cancer are summarized as follows. Structure and function of a BRCA1 gene BRCA1 gene is a tumor suppressor gene, which locates