目的引起临床医生对喹诺酮类药物应用的重视。方法根据相关文献归纳总结。结果喹诺酮类药物的主要不良反应为变态反应、神经系统毒性反应、泌尿系统不良反应、粒细胞减少等,偶发全身皮肤瘙痒、胸部闷胀、面色苍白、意识丧失、心跳骤停及听力下降、严重脱发。结论喹诺酮类药物虽然存在诸多优点,但是不良反应也很多,临床医护人员在对患者的诊治过程中,应严格遵循抗菌药物临床应用指导原则,最大限度地避免滥用药物对患者造成的不必要的损害。 Objective To arouse clinicians’ attention to the application of quinolones. Methods Based on the relevant literature summarized. Results The main adverse reactions of quinolones were allergic reactions, nervous system toxic reactions, urinary system adverse reactions, neutropenia, occasional systemic pruritus, chest swelling, pale, loss of consciousness, sudden cardiac arrest and hearing loss, severe Hair loss. Conclusion Although there are many advantages of quinolones, but there are many adverse reactions, clinical staff in the diagnosis and treatment of patients, should strictly follow the guidelines for the clinical application of antimicrobial drugs, to maximize the abuse of drugs to avoid unnecessary harm to patients .