已知抗有丝分裂药物对免疫系统有抑制作用,并已用于脏器移植和治疗免疫性疾病。但在临床实践中,抗微生物药物对免疫系统的作用却被忽视。由于抗微生物药物化疗通常时间短暂,许多观察不够透彻。然而,结核病、麻风、深部骨感染、全身性真菌病、寻常痤疮、风湿热及多发性尿道感染的治疗都需要长期服药。免疫机制在上述某些疾病的发病机理中起主要作用,它对病情恢复也很重要。因而有必要了解抗微生物药物对免疫系统的潜在作用。在已被研究过 It is known that anti-mitotic drugs have an inhibitory effect on the immune system and have been used in organ transplantation and in the treatment of immune diseases. However, in clinical practice, the antimicrobial effect on the immune system has been neglected. Because antimicrobial chemotherapy is usually short-lived, many observations are not thorough enough. However, long-term medication is required for the treatment of tuberculosis, leprosy, deep bone infections, systemic mycosis, acne vulgaris, rheumatic fever and multiple urinary tract infections. Immune mechanisms play a major role in the pathogenesis of some of these diseases and are also important for their recovery. It is therefore necessary to understand the potential effects of antimicrobial drugs on the immune system. Have been studied before