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大骨节病主要在骨关节系统发生病变。但是,病人常伴有不同程度的肌萎缩。病理学上,亦报告有骨骼肌的萎缩和坏死性病变。沈阳医学院病理等教研组(1959年)报告,大骨节病人尿肌酸排出比正常人显著增多,尿肌酐排出比正常人显著减少。我们在一次测定大骨节病人尿酸性粘多糖 S~(35)掺入的工作中曾附带测定了病人24小时尿肌酸肌酐排泄量,试图在我省的病例取得验证。现报告测定结果,并结合有关资料,对其意义作一初步探讨。
Kashin-Beck disease mainly occurs in the bone and joint diseases. However, patients are often accompanied by varying degrees of muscle atrophy. Pathologically, atrophic and necrotic lesions of skeletal muscle have also been reported. Shenyang Medical College Pathology and other research group (1959) reported that patients with urinary creatine urinary Kaga significantly increased more than normal, urinary creatinine was significantly lower than normal. In a determination of uric acid mucopolysaccharide S ~ (35) incorporated into the work of patients with Kashin-ku, we measured the 24-hour urine creatinine excretion of patients, trying to verify the cases in our province. Now report the test results, combined with the relevant information on its significance to make a preliminary discussion.