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目的探讨骨源性碱性磷酸酶(BALP)活性测定对小儿佝偻病的诊断价值。方法沈阳市皇姑区龙江社区卫生服务中心于2006-04~2007-10,采用全血干化学和免疫浓缩技术,对0~4岁216例小儿进行血液中BALP活性检测,并按1986年卫生部颁发的“婴幼儿佝偻病防治方案”对本组小儿进行佝偻病体征筛查,对12例可疑小儿进行手腕关节X线检查。结果216例小儿中BALP阳性率20.37%,其中以0~1岁组阳性率最高;12例有佝偻病临床体征小儿BALP与性别没有显著关联。结论BALP检测方法简单,对小儿佝偻病的早期诊断、疗效观察及预防具有临床意义。
Objective To investigate the diagnostic value of bone alkaline phosphatase (BALP) activity in children with rickets. Methods Lung River Community Health Service Center of Huanggu District of Shenyang City in 2006-04 ~ 2007-10, using whole blood stem cell chemistry and immunoconcentration technology, 216 children aged 0 to 4 years of blood BALP activity test, according to 1986 Ministry of Health issued the “prevention and treatment of infant rickets program” on the group of children rickets signs screening, 12 cases of suspected pediatric wrist X-ray examination. Results The positive rate of BALP in 216 children was 20.37%, of which the positive rate was the highest in 0-1 years old group. There was no significant correlation between BALP and sex in 12 children with clinical signs of rickets. Conclusion The method of BALP detection is simple and has clinical significance for the early diagnosis, curative effect and prevention of pediatric rickets.