膀胱癌是人类恶性肿瘤之一,其发病率居泌尿系统恶性肿瘤之冠,目前临床所采用的治疗方法并不彻底,肿瘤复发率高。少数报道高达70%。从1983年始,本组进行了光动力学阻断膀胱癌前病变和治疗膀胱癌的实验研究。经过7年努力在国内首次应用N-丁基-N(4-羟丁基)亚硝胺(BBN)成功诱发大鼠膀胱移行细胞癌及癌前病变模型,可诱发 Bladder cancer is one of the human malignant tumors, and its incidence rate ranks the highest in urinary malignancies. Currently, the clinical treatment methods used are not complete, and the tumor recurrence rate is high. A few reports up to 70%. Since 1983, this group has conducted experimental studies of photodynamic blocking of bladder precancerous lesions and treatment of bladder cancer. After 7 years of efforts to use N-butyl-N (4-hydroxybutyl) nitrosamine (BBN) for the first time in the country to successfully induce rat bladder transitional cell carcinoma and precancerous lesion model, it can induce