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以本组1只23月龄615雄性小鼠自发肺腺癌(I615PAC-8811)为瘤原,用本组同源小鼠作宿主,按“瘤原—宿主”体内双相选育原则进行皮下移植传代。经过6年(1986年4月～1992年4月)时间,选建出两株高自发双相(肺和浅表淋巴结)转移模型,即结节(nodule)型肺转移和弥漫(diffuse)型肺转移模型。截至1992年4月,前者已传30代,肺转移率为100%;后者已传50代,肺转移率为100%;浅表淋巴结于7代后转移率亦为100%。两型来源同一,病理组织学特征相似,但两者许多生物学性状包括药敏和移植瘤生长速度存在差异。
A spontaneous lung adenocarcinoma (I615PAC-8811) of a 615 male mouse, 23 months old in this study, was used as a tumor. The homologous mouse was used as a host, and the principle of biphasic selection according to the original tumor-host in vivo. Subcutaneous transplants were performed. After six years (April 1986 to April 1992), two highly spontaneous biphasic (lung and superficial lymph nodes) metastasis models, namely nodule-type lung metastases and diffuse types, were constructed. Lung metastasis model. As of April 1992, the former had been transmitted for 30 generations, and the rate of lung metastasis was 100%; the latter had been transmitted for 50 generations, and the rate of lung metastasis was 100%; the metastatic rate of superficial lymph nodes was also 100% after 7 passages. The two types have the same source and their histopathological features are similar. However, many biological traits, including drug sensitivity and growth rate of transplanted tumors, are different.