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近年来对维生素D受体(VDR)基因和骨量关系的研究颇有争议。有许多研究认为维生素D受体基因多态性与骨量有关联。但还有一部分研究未能证实VDR基因多态性与骨量的关联。本文就VDR基因与钙吸收、骨量、药物治疗的关系和VDR基因的协同作用以及与其它基因、环境因素的交互作用对骨量影响的研究进展进行了综述。
In recent years, the study on the relationship between vitamin D receptor (VDR) gene and bone mass has been controversial. There are many studies that associate vitamin D receptor gene polymorphism with bone mass. However, there are still some studies failed to confirm the association of VDR gene polymorphism with bone mass. This review summarizes the effects of VDR gene on calcium absorption, bone mass, drug therapy and the synergistic effect of VDR gene and its interaction with other genes and environmental factors.