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目的通过分析体外受精一胚胎移植治疗患者的染色体核型,探讨生殖异常患者细胞遗传学的临床效应。方法回顾性调查分析珠海市妇幼保健院2002年1月-2011年12月生殖中心门诊共2705例患者的染色体核型。结果 2705例行体外受精一胚胎移植治疗患者中,染色体异常174例,异常率为6.4%。其中,染色体多态72例(41.4%);倒位55例(31.6%);易位22例(12.6%);性染色体异常24例(13.8%);其他1例(0.6%)。结论染色体异常与生殖异常密切相关,染色体检查可对行体外受精一胚胎移植治疗患者的病因作出明确的诊断,从而减少患者其他不必要的治疗及指导优生。
Objective To investigate the clinical effects of cytogenetics in patients with genital abnormalities by analyzing the chromosome karyotype of patients undergoing in vitro fertilization and embryo transfer. Methods The chromosomal karyotypes of 2705 cases of reproductive center clinics in Zhuhai MCH from January 2002 to December 2011 were analyzed retrospectively. Results 2705 routine in vitro fertilization and embryo transfer treatment of patients, 174 cases of chromosomal abnormalities, the abnormal rate was 6.4%. Among them, 72 (41.4%) were polymorphic; 55 (31.6%) were inverted; 22 (12.6%) were translocated; 24 (13.8%) had sex chromosome abnormality; Conclusion Chromosomal abnormalities are closely related to reproductive abnormalities. Chromosome examination can make a definite diagnosis of the etiology of patients undergoing in vitro fertilization and embryo transfer, so as to reduce other unnecessary treatment and guidance of eugenics.