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c-myc原癌基因编码产物与核内DNA特异性结合,其表达受特异类型的生长信号的诱导,并呈细胞周期依赖性。在正常细胞的静止状态和终末分化后,c-myc表达受抑,其异常表达参与肿瘤细胞的增殖和分化过程的调节,在白血病中它的异常激活机制包括染色体移位、基因扩增、点突变、启动子插入激活及c-myc mRNA水平的异常表达。c-myc原癌基因表达水平的检测对白血病的病程演进,疗效评价和预后估计均有一定意义。
The product encoded by the c-myc proto-oncogene specifically binds to nuclear DNA, and its expression is induced by a specific type of growth signal and is cell-cycle dependent. After quiescence and terminal differentiation of normal cells, c-myc expression is inhibited, and its abnormal expression is involved in the regulation of tumor cell proliferation and differentiation. Its abnormal activation mechanisms in leukemia include chromosome translocation, gene amplification, Point mutations, promoter insertions, and abnormal expression of c-myc mRNA levels. The detection of the expression level of c-myc proto-oncogene has certain significance for the progression of leukemia, evaluation of therapeutic effect and estimation of prognosis.