恶性黑色素瘤有较高的局部复发和全身转移率,且容易发生多原发瘤(MPM)。本文就1972年来杜克大学癌症中心收治的7816例黑色素瘤进行回顾,分析其发病率、高危因素和预后。7816例中283例为MPM,占3.6%。两个原发瘤占82%,3个占11%,4个占3%,最多为9个。同时发生的占36%,先后发生的占64%。黑色素瘤 Malignant melanoma has a high rate of local recurrence and systemic metastasis and is prone to multiple primary tumors (MPM). This article reviews 7,816 melanomas treated at the Duke University Cancer Center in 1972 and analyzes their incidence, risk factors, and prognosis. Of the 7816 cases, 283 were MPM, accounting for 3.6%. Two primary tumors accounted for 82%, 3 accounted for 11%, 4 accounted for 3%, and a maximum of 9 patients. At the same time accounted for 36%, 64% occurred in succession. Melanoma