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目的:观察中药温肾止遗方治疗肾虚型小儿遗尿症的临床疗效并探讨其作用机制。方法:90例遗尿症患儿,采用温肾止遗方治疗30例,弥凝治疗30例,联合治疗30例。分别于用药1、2月及停药半年总结疗效,并ELISA法检测血浆抗利尿激素(ADH)水平的变化。结果:联合组和温肾止遗组症状改善明显优于弥凝组,有显著性差异(P<0.05);用药1月后比较,联合组疗效和弥凝组疗效明显优于温肾止遗方组,有显著差异(P<0.05);用药2月后比较,3组疗效接近,无显著性差异(P>0.05);停药半年后比较,温肾止遗组和联合组明显优于弥凝组,有极显著性差异(P<0.01)。3组治疗后ADH水平较疗前明显增加。结论:温肾止遗方治疗小儿遗尿症疗效可靠,增加ADH水平是其作用机制之一。
Objective: To observe the clinical efficacy of Wenshenzhiyang Decoction in treating children with enuresis of kidney deficiency and to explore its mechanism. Methods: Ninety children with enuresis were treated with Wenshen Decoction 30 cases, Ditan condensate 30 cases and combination therapy 30 cases. Respectively in January and February of medication and drug withdrawal six months to summarize the efficacy, and ELISA assay of plasma anti-diuretic hormone (ADH) levels. Results: The improvement of symptoms in combination group and Wenshenzhi group was significantly better than that in Mi-Ning group (P <0.05). Compared with those in Mizhuang group after 1 month of treatment, the curative effect in combination group and Mi-Ning group was significantly better than those in Wenshenzhi (P <0.05). After 2 months of treatment, the curative effect of the three groups was similar (P> 0.05). Compared with the control group after 6 months, Coagulation group, there is a very significant difference (P <0.01). The ADH levels in the three groups were significantly increased after treatment. Conclusion: Wenshen Decoction for the treatment of children with enuresis is reliable and increase the level of ADH is one of its mechanisms.