用人Ｃ－Ｈａ－ｒａｓ－１全长基因组ＤＮＡ作探针，对３８例双相型情感性精神病人和正常对照人群６６人进行ＲＦＬＰ分析，ＳａｃＩ酶解产生５．２ｋｂ，５．７ｋｂ，６．２ｋｂ和６．８ｋｂ四种等位多态片段，但各等位片段的频率与北美人比较有较大差别。ＢＰ病人和正常人之间，等位片段分布及等位片段组成的基因型分布均无显著差异。对４个ＢＰ家系进行分析，其中两个家系可见到等位片段分离现象，但基因传递和情感性精神病之间的关系难以确定。研究结果不支持情感性精神病与Ｈａ－ｒａｓ基因连锁。 RFLP analysis was performed on 66 bi-phase emotional psychotic patients and 66 normal controls using the full-length genomic DNA of human C-Ha-ras-1 as a probe. SacI digestion produced 5.2 kb, 5.7 kb, 6. 2kb and 6.8kb four kinds of allelic polymorphic fragments, but the frequency of each allele compared with North Americans are quite different. There was no significant difference in genotype distribution between alleles and fragments between BP patients and normal subjects. Four BP families were analyzed, of which two families showed allelic segregation but the relationship between gene delivery and affective psychosis was difficult to determine. The results do not support the emotional psychosis linked to the Ha-ras gene.