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目的：探讨烧伤休克后立即和延迟输液对肺功能的影响。方法：４３只犬被随机分为四组，①正常对照组，②立即输液组，③延迟输液组，④不输液组。除正常对照组外，所有犬都造成５０％Ⅲ度体表烧伤。血气分析、ＣＯ、ＦＡＰ等在伤后０．５、２、６、１２、１８、２４、３６、４８小时观测。所有犬除不输液组外，伤后按Ｐａｒｋｌａｎｄ公式静脉补液。结果：正常对照组和立即输液组伤后ＰａＯ２、ＰａＣＯ２、ＣＯ、ＦＡＰ等无明显变化。不输液组所有犬伤后１２小时内死于烧伤休克，但ＰａＯ２、ＰａＣＯ２无明显变化。延迟输液组所有犬显示严重休克，低氧血症，呼吸性碱中毒，代谢性酸中毒，血ＳＯＤ明显降低，肺ＭＤＡ和肺水量明显增加，同正常对照组和立即输液组比较，其中８６．７％的犬死于烧伤休克。结论：延迟输液组肺功能不全，除了烧伤休克和烧伤本身影响外，与延迟输液引起再灌注损害，产生氧自由基导致脂质过氧化和肺毛细血管通透性增加，加重肺水肿，从而影响肺功能有关。
Objective: To investigate the effects of infusion immediately and delayed infusion on lung function after burn shock. Methods: Forty-three dogs were randomly divided into four groups: ① normal control group, ② immediate infusion group, ③ delayed infusion group, ④ no infusion group. Except normal control group, all dogs caused 50% Ⅲ degree surface burn. Blood gas analysis, CO, FAP and other 0.5,2,6,12,18,24,36,48 hours after injury observed. All dogs except the infusion group, Parkland formula by intravenous rehydration after injury. Results: PaO2, PaCO2, CO, FAP, etc in normal control group and immediate infusion group had no significant changes. No transfusion group all dogs died of burn shock within 12 hours after injury, but PaO2, PaCO2 no significant change. Delayed infusion group, all dogs showed severe shock, hypoxemia, respiratory alkalosis, metabolic acidosis, blood SOD was significantly lower lung MDA and lung water volume was significantly increased, compared with the normal control group and immediate infusion group, of which 86. Seven percent of dogs died of burn shock. Conclusion: Delayed infusion group pulmonary insufficiency, in addition to the impact of burn shock and burn itself, delayed infusion caused reperfusion damage, produce oxygen free radicals lead to lipid peroxidation and increased pulmonary capillary permeability, increased pulmonary edema, thus affecting Pulmonary function.