报道108例垂体大腺瘤(直径>2cm)117次经蝶窦显微手术和5次开颅手术后随访6月～14年的结果。男62例,女46例。年龄19～73岁。垂体瘤全切除术后CT复查未发现残余肿瘤组织者占41%。25%催乳素腺瘤及20%的生长激素腺瘤达到内分泌治愈。术后复发率12.7%,大多发生在术后4～8年。 A total of 108 cases of large pituitary adenomas (diameter>2cm) were reported for 117 transsphenoidal sinus microsurgery and 5 craniotomy cases. Follow-up results from June to 14 years were reported. There were 62 males and 46 females. Age 19 to 73 years old. After resection of pituitary tumors, no recurrence of tumor tissue was found in 41% of patients who underwent CT reexamination. 25% prolactinoma and 20% growth hormone adenoma reached endocrine cure. The postoperative recurrence rate was 12.7%, mostly occurring 4 to 8 years after surgery.