论文部分内容阅读
肿瘤是国际上最难征服的疾病之一。肿瘤细胞具有生长迅速,向正常组织浸润及转移扩散等特点。传统对付肿瘤的方法不但能杀死肿瘤细胞,同时正常细胞也不可避免的遭到杀伤。1971年哈佛大学医学院Folkman教授首先提出恶性肿瘤生长和转移依赖于肿瘤新生血管的新观点,由此开创了肿瘤血管形成和抗血管治疗的研究,因此,抑制肿瘤新生血管的形成,促使肿瘤细胞进入休眠状态或诱发——是治疗肿瘤的有效途径之一。目前,抑制血管生长的因子主要有:白介素12(interleukin-12),干扰素(INF-α/β),血小板因子4(ploteletfactor-4),内皮抑制素(endostatin)及血管抑制素(angiostatin)等。其
Tumor is one of the most difficult diseases in the world to conquer. Tumor cells have the characteristics of rapid growth, infiltration and metastasis to normal tissues. Traditional methods of dealing with tumors not only kill tumor cells, but also kill normal cells. In 1971, Folkman, professor of medicine at Harvard Medical School, first proposed a new viewpoint that malignant tumor growth and metastasis depend on tumor neovascularization, thus creating a study on tumor angiogenesis and anti-angiogenesis. Therefore, inhibiting tumor angiogenesis and promoting tumor cells Into the dormant state or induced - is an effective way to treat cancer. At present, the main factors inhibiting blood vessel growth are: interleukin-12, INF-α / β, ploteletfactor-4, endostatin and angiostatin. Wait. its