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目的探讨血清降钙素原(PCT)在呼吸机相关性肺炎(VAP)诊断中的临床应用价值。方法对48例VAP确诊患者48 h内行PCT、C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞百分比(N)及体温(T)测定。同时对60例非VAP患者和20例健康体检者进行相关指标测定。结果 VAP组PCT高于非VAP组及正常对照组,差异有统计学意义(P<0.01),非VAP组与正常对照组间差异无统计学意义(P>0.05);PCT诊断VAP的敏感性为83.3%,特异性为88.3%。结论血清PCT在VAP的诊断中有较高的敏感性和特异性,优于传统的炎性指标,及时监测血清PCT可能有助于VAP的早期诊断和治疗。
Objective To investigate the clinical value of serum procalcitonin (PCT) in the diagnosis of ventilator-associated pneumonia (VAP). Methods The 48 patients diagnosed by VAP were examined for PCT, C reactive protein (CRP), white blood cell count (WBC), neutrophil percentage (N) and body temperature (T) within 48 h. At the same time, 60 non-VAP patients and 20 healthy subjects were measured. Results The PCT of VAP group was higher than that of non-VAP group and normal control group (P <0.01), but there was no significant difference between non-VAP group and normal control group (P> 0.05) 83.3% and specificity of 88.3%. Conclusions Serum PCT has a higher sensitivity and specificity in the diagnosis of VAP than conventional inflammatory markers, and timely monitoring serum PCT may be helpful for the early diagnosis and treatment of VAP.