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目的探讨检测细胞免疫功能在病毒性心肌炎患者中的变化及其临床应用价值。方法 80例病毒性心肌炎患者作为研究组,80例体检健康者作为对照组,对两组的细胞免疫功能进行测定,并比较研究组治疗前后细胞免疫功能的变化情况。结果研究组治疗前CD3+、CD4+、CD8+、CD4+/CD8+均明显低于本组治疗后和对照组(P<0.05)。研究组治疗前自然杀伤细胞(NK)、肿瘤坏死因子(TNF)水平分别为(28.5±5.3)%、(35.6±6.3)g/L,均明显低于本组治疗后和对照组(P<0.05)。研究组治疗后CD3+、CD4+、CD8+、CD4+/CD8+、NK、TNF水平与对照组比较差异无统计学意义(P>0.05)。结论临床中病毒性心肌患者细胞免疫功能低下,检测其免疫功能对临床诊治具有重要的应用价值。
Objective To investigate the changes of cellular immune function in patients with viral myocarditis and its clinical value. Methods Eighty patients with viral myocarditis were selected as research group and 80 healthy controls as control group. The cellular immune function of the two groups was measured, and the change of cellular immunity before and after treatment was compared. Results Before treatment, the levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + of the study group were significantly lower than those of the control group and the control group (P <0.05). The levels of natural killer (NK) and tumor necrosis factor (TNF) in the study group before treatment were (28.5 ± 5.3)% and (35.6 ± 6.3) g / L, respectively, which were significantly lower than those in the control group and the control group 0.05). The levels of CD3 +, CD4 +, CD8 +, CD4 + / CD8 +, NK and TNF in the study group were not significantly different from those in the control group (P> 0.05). Conclusions In clinical patients with viral myocarditis, cellular immune function is low, and its immune function is of great value in clinical diagnosis and treatment.