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19世纪中期在墨西哥高源工作的法国医生DenisJourdanet提出红细胞增多与缺氧有关。他和他的同道Part Bert认为50年来提供的资料概念不够清楚,证据不能令人信服。1950年Reissmann指出处于低氧状态下老鼠能传递一种红细胞生成刺激物给另一只正常老鼠。引起对这一研究的新的兴趣。1953年Erslev等证实这种刺激物或因子存在于贫血免子的血浆中。随后又证实这种刺激物或因子在控制红细胞生成速度方面起一定作用.又证实这种因子在肾缺氧时生成并作用于骨髓造血细胞。1957年Jacobson及其同事从无肾鼠的研究中断定促红细胞生成素(Ery-thropoiefine,EPO)是由肾脏产生,并揭示肾内促红细胞生成素及其信使核糖核酸,并大胆设想肾性贫血与肾性激素有关系,如果能获得大量的
Denis Jourdanet, a French doctor who worked at Highland, Mexico in the mid-19th century, said that increased red blood cells are associated with hypoxia. He and his fellow citizens, Part Bert, believe the concept of information provided over the past 50 years is not clear enough and the evidence is not convincing. Reissmann in 1950 pointed out that in hypoxia, mice can deliver an erythropoietic stimulus to another normal mouse. Aroused new interest in this research. 1953 Erslev et al confirmed that such stimuli or factors exist in the anemia-free plasma. It was subsequently confirmed that this stimulus or factor plays a role in controlling the rate of erythropoiesis, confirming that this factor is produced and acts on myeloid hematopoietic cells during kidney hypoxia. In 1957, Jacobson and colleagues concluded from the study of non-renal rats that Erythropoietin (EPO) is produced by the kidneys and reveals intrarenal erythropoietin and its messenger ribonucleic acid, and boldly envisions renal anemia And kidney sex hormones, if you can get a lot of