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目的对硫酸镁联合尼卡地平治疗重度子痫前期临床疗效进行观察。方法 96例重度子痫前期患者,随机分为治疗组(硫酸镁联合尼卡地平治疗)和对照组(单用尼卡地平治疗),各48例。观察两组血压变化、胎儿评分及产后出血情况。结果治疗后,治疗组收缩压及舒张压分别为(141.3±15.5)、(93.2±12.1)mm Hg(1 mm Hg=0.133 k Pa),对照组分别为(157.6±16.7)、(106.3±13.5)mm Hg,治疗组下降优于对照组,差异有统计学意义(P<0.05)。治疗后治疗组胎儿评分高于对照组(P<0.05)。两组均不增加产后出血风险。结论硫酸镁联合尼卡地平治疗重度子痫前期综合效果显著,更能有效降低血压,改善胎儿缺氧状态,并不增加产后出血的风险,值得临床推广使用。
Objective To observe the clinical effect of magnesium sulfate combined with nicardipine in the treatment of severe preeclampsia. Methods 96 patients with severe preeclampsia were randomly divided into treatment group (magnesium sulfate combined with nicardipine treatment) and control group (nicardipine alone), 48 cases in each. The changes of blood pressure, fetal score and postpartum hemorrhage were observed. Results After treatment, the systolic and diastolic blood pressure of the treatment group were (141.3 ± 15.5) and (93.2 ± 12.1) mm Hg (1 mm Hg = 0.133 k Pa), respectively, and were 157.6 ± 16.7 and 106.3 ± 13.5 ) mm Hg, the treatment group decreased better than the control group, the difference was statistically significant (P <0.05). After treatment, the fetus score of treatment group was higher than that of control group (P <0.05). Neither group increased the risk of postpartum hemorrhage. Conclusion Magnesium sulfate combined with nicardipine treatment of severe preeclampsia significant effect, more effective in lowering blood pressure and improve fetal hypoxia, does not increase the risk of postpartum hemorrhage, it is worth promoting the use of the clinic.