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Background Although mi RNAs have been shown to associate with a variety of diseases,whether mi RNAs in monocyte associate heart failure(HF) has been not well studied.Methods Eight patients with ischemic HF(IHF),8 patients with non-ischemic HF(NIHF) and 8 healthy volunteers were recruited.Clinical characteristics of all participants were collected.Peripheral blood samples were drawn for analysis of mi RNA expression in monocytes.Results All participants were male and the participants in IHF group were older and had higher percentage of smoker and diabetes mellitus than in the other two groups(P < 0.05).Serum levels of creatinine and NT-pro BNP were significantly higher in IHF patients compared to the other two groups(P < 0.05).More participants in IHF group were treated with ACEI/ARB,beta-blocker and statins.Participants with NYHA grade III accounted for 62.5% in IHF group,while participants with NYHA grade IV accounted for 87.5% in NIHF group.The levels of 11 mi RNAs in monocytes were significantly higher in the IHF group,and the levels of 7 mi RNAs were significantly increased in the NIHF group.Other differences in mi RNAs levels between IHF and NIHF groups were also observed.Conclusion our present study revealed that there are substantial differences in mi R-NAs between HF patients and healthy volunteer.
Background Although miRNAs have been shown to associate with a variety of diseases, whether mi RNAs in monocyte associate heart failure (HF) has been not well studied. Methods Eight patients with ischemic HF (IHF), 8 patients with non-ischemic HF Clinical indicators of all participants were collected. Clinical peripherals samples were analyzed for miRNA expression in monocytes. Results All participants were male and the participants in IHF group were older and had higher percentage of smoker and diabetes mellitus than in the other two groups (P <0.05) .Serum levels of creatinine and NT-pro BNP were significantly higher in IHF patients compared to the other two groups (P <0.05) .More participants in IHF group were treated with ACEI / ARB, beta-blocker and statins. Participants with NYHA grade III accounted for 62.5% in IHF group, while participants with NYHA grade IV accounted for 87.5% in NIHF group. The levels of 11 mi RNAs in monocytes were significantly higher in the IHF group, and the levels of 7 mi RNAs were significantly increased in the NIHF group. Other differences in miRNAs levels between IHF and NIHF groups were also observed. Confclusion our present study revealed that there are substantial differences in mi R -NAs between HF patients and healthy volunteer.