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目的探讨急性冠状动脉综合征(ACS)患者发病早期,外周血心型脂肪酸结合蛋白(H FABP)水平对预后的预测价值。方法筛选明确诊断ACS患者677例,测定入院首次(发病<1 2 h)外周血H-FABP水平,并随访观察1、6个月和≥1 2个月时心血管不良事件。根据H-FABP水平,分为≤120.56μg/L组(低值组)509例和>120.56μg/L组(高值组)168例,比较H FABP水平和心血管不良事件的关系。结果与低值组比较,高值组1、6个月和≥12个月心因性死亡OR值分别为5.706、2.825和1.108,非致死性心肌梗死OR值分别为5.1 74、2.572和3.361,非致死性心力衰竭OR值分别为3.105、2.723和2.672。多因素logistic回归分析显示,H-FABP是ACS患者发病1、6个月和≥12个月发生复合终点事件的独立危险因素(P<0.05,P<0.01)。结论发病早期H-FABP水平升高是ACS患者再发心血管不良事件的独立危险因素。
Objective To investigate the prognostic value of the levels of peripheral HbA1c (FABP) in patients with acute coronary syndrome (ACS) at the early onset of disease. Methods A total of 677 patients with ACS were enrolled in this study. H-FABP level in the peripheral blood of the first admission (onset <12 h) was determined. Follow-up was performed to investigate cardiovascular adverse events at 1,6 months and ≥12 months. According to the level of H-FABP, there were 168 cases of ≤120.56μg / L group (low value group) and> 120.56μg / L group (high value group), and the relationship between H-FABP level and cardiovascular adverse events was compared. Results Compared with the low-value group, the OR of high-value group at 1,6 and 12 months were 5.706, 2.825 and 1.108, respectively. The OR of non-fatal myocardial infarction were 5.174, 2.572 and 3.361, OR of non-fatal heart failure were 3.105, 2.7223 and 2.672 respectively. Multivariate logistic regression analysis showed that H-FABP was an independent risk factor for ACS at 1, 6 months and 12 months (P <0.05, P <0.01). Conclusions The high level of H-FABP in the early stage of onset is an independent risk factor of recurrent cardiovascular events in patients with ACS.