变应性亚败血症(Subsepsisallerqica)又称Wisgler—Fanconi综合征,临床上以反复长期发热、皮疹、关节肌肉酸痛为三大主症.本症抗菌治疗无效,激素虽可控制症状,但常有复发.长期应用且多副作用.我科1974～1992年以中药为主中西医结合治疗14例,经18年随访,疗效满意,现报告如下.1 临床资料1.1 一般资料 本组14例男6例,女8例,年龄13～49岁.以青少年多见.1.2 临床表现①发热14例均因长期发热住院,其中12例突然高热起病,2例低热1周后出现高效,呈间歇性持续高热.5例呈弛张热,除3例多汗外,余多微汗.病人均神志清楚,除轻度乏力、头痛外无其它不适.③14例均有皮疹出现,其形态不定,大小不等,或融合成片,或呈充血性,压之退色,无痛痒,其中1例可见色素沉着;皮疹常随发热出现,热退疹亦退;多见于胸背部,颈、面、四肢、手足少见.③关节肌肉酸痛14例中9例关节痛,多出现于四肢大关节,有游走性,绝大多数无红肿,1例以小关节痛为主.肌肉、关节酸痛与发热呈正比,高热时关节痛较重,热退后则痛减.④其它:14例中10例咽部不同程度充血.2例扁桃体Ⅱ°肿大,9例淋巴结肿大,以颌、颈、腋、腹股沟多见,压痛阳性,2例肝脾肿大.1.3 实验室检查 本病实验室检查无特异性.血常规:白细胞总数增高,可达15～40×10~(?)/L,甚则出现核左移,有的轻 Subsepsisallerqica also known as Wisgler-Fanconi syndrome, clinically repeated long-term fever, rash, joint muscle soreness for the three main symptoms of this disease is not effective antibacterial therapy, although the hormone can control the symptoms, but often relapse Long-term application and many side effects. Our department from 1974 to 1992, mainly in traditional Chinese medicine treatment of 14 cases, 18 years follow-up, the results are satisfactory, are as follows.1 Clinical data 1.1 General Information The group of 14 males in 6 cases, 8 females, aged 13 to 49 years old to more common in adolescents.1.2 clinical manifestations ① fever in 14 cases were hospitalized for long-term fever, of which 12 cases of sudden onset of fever, fever hypothermia in 2 cases after 1 week showed intermittent continuous high fever .5 cases showed relaxation fever, except for 3 cases of hyperhidrosis, more than a little sweat.Patients were conscious, with mild fatigue, no other discomfort outside the headache.③14 cases have a rash, its shape is variable, the size range , Or into a film, or was congestive, pressure of the fade, no itch, one case of visible pigmentation; rash often with fever, fever and rash also retreat; more common in the chest and back, neck, face, limbs, hand, foot and rare .③ Joint pain was found in 9 cases of joint pain in 14 cases, mostly in the joints of limbs , There is migration, the vast majority of no swelling, a case of joint pain mainly muscle, joint pain and fever was proportional to high fever, severe joint pain, heat back pain reduction .④Other: 14 cases 10 cases of pharyngeal congestion to varying degrees .2 cases of tonsil Ⅱ ° enlargement, 9 cases of lymph nodes, with jaw, neck, axillary, groin more common, tenderness positive, 2 cases of hepatosplenomegaly.1.3 laboratory tests of the disease Laboratory examination of non-specific blood routine: the total number of leukocytes increased up to 15 ~ 40 × 10 ~ (?) / L, and even appear left nuclear shift, and some light