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目的观察胰岛素短期强化治疗对初诊2型糖尿病(T2DM)患者的胰岛β细胞功能的影响。方法对空腹血糖(FPG)≥10mmol/L的35例住院初诊断T2DM患者行胰岛素强化治疗,治疗前及治疗血糖达标后行糖化血红蛋白(HbAlc)、口服葡萄糖耐量试验(OGTT)、胰岛素释放试验(OGIRT)检测;对血糖控制情况、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、早时相胰岛素分泌指数(△I30/△G30)进行比较。结果治疗后HbAlc、OGTT各时点血糖和HOMA-IR均明显降低(P<0.05),OGIRT各时点胰岛素(Ins)、HOMA-β和△I30/△G30明显升高(P<0.05)。结论短期胰岛素强化治疗对新诊断T2DM是既安全又能有效控制血糖水平、减低胰岛素抵抗、使胰岛β细胞功能恢复的治疗方案,对延缓糖尿病自然病程的进程,预防糖尿病慢性并发症有积极的意义。
Objective To observe the effect of short-term intensive insulin therapy on pancreatic β-cell function in newly diagnosed type 2 diabetes mellitus (T2DM). Methods 35 cases of newly diagnosed T2DM patients with fasting plasma glucose (FPG) ≥10mmol / L underwent insulin intensive therapy. Before treatment and after reaching the blood glucose level, HbAlc, oral glucose tolerance test (OGTT), insulin release test OGIRT). The levels of blood glucose control, HOMA-β, HOMA-IR and △ I30 / △ G30 were compared. Results The blood glucose and HOMA-IR of HbA1c and OGTT were significantly decreased (P <0.05), and the levels of Ins, HOMA-β and △ I30 / △ G30 in OGIRT group were significantly increased after treatment (P <0.05). Conclusions Short-term intensive insulin treatment of T2DM is safe and can effectively control the blood glucose level, reduce insulin resistance, the function of pancreatic β-cell recovery of the treatment program, to delay the course of diabetes, the natural course of progression, prevention of chronic complications of diabetes has a positive meaning .