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目的 :探讨 CD44 V6与胃癌发生、发展及转移的关系。方法 :采用 SP免疫组化法检测 10 6例胃癌及癌旁异型增生和癌旁正常胃粘膜上皮 CD44 V6的表达。结果 :胃癌 CD44 V6阳性表达率为 6 3.2 % ,明显高于癌旁异型增生和癌旁正常胃粘膜上皮的32 .4%和 9.1%阳性表达率。胃癌侵及浆膜层组、有淋巴结转移组及临床 TNM 、 期病人 CD44 V6阳性表达率明显高于未侵及浆膜层组、无淋巴结转移组及临床 TNM 、 期病人 (P<0 .0 1,P<0 .0 1,P<0 .0 5 )。结论 :CD44 V6阳性表达预示胃癌具有较强的侵袭转移能力 ,CD44 V6基因蛋白可作为一项预测胃癌转移潜能的生物学指标、检测胃癌组织中 CD44 V6的表达对判断预后和指导临床治疗有较重要的应用价值
Objective: To investigate the relationship between CD44 V6 and the occurrence, development and metastasis of gastric cancer. Methods: SP immunohistochemical method was used to detect the expression of CD44 V6 in 106 cases of gastric cancer, adjacent dysplasia and adjacent normal gastric mucosa epithelium. Results: The positive expression rate of CD44 V6 in gastric cancer was 62.2%, which was significantly higher than that of normal gastric mucosa adjacent to carcinoma and 32.4% and 9.1% respectively. The positive rate of CD44 V6 in patients with gastric cancer invading serosal layer, lymph node metastasis and clinical TNM was significantly higher than that in non-invasive serosal layer, lymph node metastasis and clinical TNM (P <0. 0) 1, P <0. 01, P <0. 05). Conclusion: The positive expression of CD44 V6 indicates that gastric cancer has strong invasion and metastasis. CD44 V6 gene protein may be used as a biological index to predict the metastatic potential of gastric cancer. Detecting the expression of CD44 V6 in gastric cancer tissue may be more useful in judging the prognosis and guiding the clinical treatment Important application value