目前普遍认为骨髓增生异常综合征代表了白血病前期状态,造血干细胞的异常克隆继续发展,则引起各种各样的血液学疾病。从生存期长的慢性难治性贫血(RA)乃至有严重全血细胞减少,常转化为白血病的难治性贫血伴有过多的原始细胞(RAEB)。有报道13- It is generally accepted that myelodysplastic syndrome represents a pre-leukemic state and that abnormal clones of hematopoietic stem cells continue to develop, causing a variety of hematological disorders. From chronic long-lived refractory anemia (RA) to severe pancytopenia, refractory anemia, often converted to leukemia, is accompanied by excess of blast cells (RAEB). There are reports 13-