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目的 评价氯沙坦 (Los)与非洛地平 (Felo)治疗高血压病的临床疗效。方法 采用随机、单盲、平行对照方法 ,将 60例轻、中度高血压患者均分成 (Los)组 (3 0例 ) ,口服Los5 0～ 10 0mg/d ,疗程 4周Felo组 (3 0例 ) ,口服Felo5～ 10mg/d ,疗程 4周。每周测诊室血压 (CBP)、心率 (HR) ,治疗前后行 2 4h动态血压监测 (ABPM)。结果 4周末Los组与Felo组总有效率分别为 80 0 %与 83 4% ,与治疗前比差异非常显著 (P <0 .0 1) ,组间比无显著性差异 (P >0 .0 5 )。动态血压测定 2 4h、日间、夜间血压均值较治疗前明显下降 (P<0 .0 1) ,Los略优于Felo。收缩压 (SBP)和舒张压 (DBP)的谷峰比值 (T/P)均大于 5 0 %。不良反应Felo多于Los。结论 两种药物均不影响血压昼夜节律 ,降压谷峰比值较好 ,均为有前途的抗高血压药
Objective To evaluate the clinical efficacy of losartan and Felod in the treatment of hypertension. Methods A total of 60 mild and moderate hypertensive patients were randomly divided into three groups: Los group (30 cases), Los5-10.0 mg / d group, and Felos group Cases), oral Felo5 ~ 10mg / d, treatment for 4 weeks. Weekly test room blood pressure (CBP), heart rate (HR), 24 h before and after treatment of ambulatory blood pressure monitoring (ABPM). Results The total effective rates of Los group and Felo group were 80 0% and 83 4% respectively at the end of 4 weeks, which were significantly different from those before treatment (P <0.01), there was no significant difference between the two groups (P> 0.05) 5). Ambulatory blood pressure 2 4h, daytime and nighttime mean blood pressure was significantly lower than before treatment (P <0.01), Los slightly better than Felo. SBP and DBP peak to trough ratio (T / P) were more than 50%. Adverse reactions Felo more than Los. Conclusions Both drugs have no effect on the circadian rhythm of blood pressure, and the ratio of blood pressure and trough peak is better, both of which are promising antihypertensive drugs