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目的探讨TNF-α基因rs1800629位点多态性与汉族人群子宫颈人乳头瘤病毒(HPV)16型感染风险或HPV16型感染后子宫颈癌发生风险的相关性。方法研究入选汉族女性679名,共分为3组,分别为HPV16型阳性子宫颈癌患者204例,HPV16型阳性正常人群157例和HPV阴性正常对照人群318例。通过限制性片段多态法(PCR-RLFP)对rs1800629位点进行基因分型。结果每2组间TNF-α基因rs1800629位点的等位基因和基因型分布均无明显差异(P>0.05)。rs1800629位点多态性与HPV16型感染风险(OR=0.581,95%CI:0.211~1.598,P=0.293),与子宫颈癌发生风险(OR=1.063,95%CI:0.371~3.041,P=0.910),及与HPV16型感染后子宫颈癌发生风险(OR=0.631,95%CI:0.206~1.929,P=0.419)均无显著相关。结论我们的研究认为,TNF-α基因rs1800629位点多态性与HPV16型感染风险,子宫颈癌风险及HPV16型感染后子宫颈癌发生风险无关。
Objective To investigate the association of rs1800629 polymorphism of TNF-α gene with the risk of cervical type 16 human papillomavirus (HPV) infection or the risk of cervical cancer after HPV16 type infection in Han population. Methods Six hundred and seventy-six Han women were selected and divided into three groups: 204 cases of HPV16 positive cervical cancer, 157 cases of HPV16 positive normal group and 318 cases of HPV negative control group. Rs1800629 locus was genotyped by restriction fragment polymorphism (PCR-RLFP). Results There was no significant difference in allele and genotype distribution of TNF-α gene rs1800629 between two groups (P> 0.05). rs1800629 polymorphism was associated with HPV16 infection (OR = 0.581, 95% CI: 0.211-1.598, P = 0.293) and risk of cervical cancer (OR = 1.063, 95% CI: 0.371-3.041, P = 0.910) and the risk of cervical cancer after infection with HPV16 (OR = 0.631, 95% CI: 0.206 ~ 1.929, P = 0.419). Conclusions Our study suggests that the rs1800629 polymorphism of TNF-α gene is not associated with the risk of HPV16 infection, cervical cancer risk and the risk of cervical cancer after HPV16 infection.