论文部分内容阅读
用一种新型聚胺基糖表面处理氧化纤维口服吸附剂（ＣｇｉｔｉｓａｎＤＡＣ）对正常和慢性肾衰模型鼠进行了尿素、氨的体外吸附实验研究，ＣｈｉｔｏｓａｎＤＡＣ在用大鼠胃肠内容物的上清液进行的体外研究中表现出较高的吸附能力。而活性炭Ｋｒｅｍｃｚｉｎ对这些物质的吸附能力则较差。用含５％的ＣｈｉｔｏｓａｎＤＡＣ饲料喂养正常大鼠３周后，其于粪重量、粪内水分含量及粪中含氮量明显增加，而蛋白质表面吸收率则下降。部分结扎肾动脉制成慢性肾衰大鼠模型，用含或不含５％ＣｈｉｔｏｓａｎＤＡＣ的饲料喂养２个月。前者血中尿素氮浓度明显降低，但和后者相比，它们尿中的尿素氮含量无明显差异。提示ＣｈｉｔｏｓａｎＤＡＣ在胃肠道内对尿素和氨的吸附而促进了这些物质在粪中的排泄．ＣｈｉｔｏｓａｎＤＡＣ可降低血浆肌酐浓度，增加肌酐清除率和血红蛋白浓度。而且组织学检查表明服用ＣｈｉｔｏｓａｎＤＡＣ的大鼠其肾小球硬化程度有所减轻。这些观察提示服用ＣｈｉｔｏｓａｎＤＡＣ引起的蛋白质表面吸收率下降，干粪重量、粪内水分含量及其尿毒素排泄的增加，可能在改善慢性肾衰大鼠肾功能方面起着重要作用。
In vitro and in vitro adsorption studies of urea and ammonia in normal and chronic renal failure model rats were conducted using a novel polyglucosamine-based surface-treated oxidized fiber oral adsorbent (CgitisanDAC). ChitosanDAC was tested in vitro using supernatant of rat gastrointestinal contents In vitro studies carried out showed higher adsorption capacity. Activated carbon Kremczin adsorption of these substances is poor. Normal rats fed with 5% ChitosanDAC diet for 3 weeks showed a significant increase in fecal weight, fecal water content and fecal nitrogen content, while the protein surface absorption rate decreased. Rat models of chronic renal failure were partially established by ligation of the renal arteries and were fed with 5% ChitosanDAC for 2 months. The former blood urea nitrogen concentration was significantly lower, but compared with the latter, their urine urea nitrogen content was no significant difference. It is suggested that ChitosanDAC promotes the excretion of these substances in feces by adsorbing urea and ammonia in the gastrointestinal tract. ChitosanDAC reduces plasma creatinine concentration and increases creatinine clearance and hemoglobin concentration. And histological examination showed that rats taking ChitosanDAC glomerular sclerosis degree of relief. These observations suggest that the reduction in protein surface absorption caused by ChitosanDAC administration may contribute to the improvement of renal function in rats with chronic renal failure due to decreased dry weight, increased water content in the feces, and increased uremic excretion.