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利多卡因对急性心肌梗塞早期的疗效较差,20～30％的患者对通常剂量的利多卡因不起效应,其中17～18％的病人对利多卡因呈抗药性。抗心律失常药物包括普鲁卡因酰胺、奎尼丁、心得安和苯妥英钠,单独或联合应用的疗效不一,为此,很需要有新的药物。双异丙吡胺是一种新的抗心律失常药物,可以口服,也可以静脉滴注,是一种“Ⅰ型”药物,减少钠的细胞内流,延长动作电位时限和制止起搏点电位。本文报道随机比较利多卡因和双异丙吡胺对制止室性心律失常的疗效。方法:(1)随机试验:26例每分钟有≥4个室
Lidocaine is less effective in the early stages of acute MI, and 20 to 30% of patients do not respond to the usual dose of lidocaine, with 17 to 18% being resistant to lidocaine. Antiarrhythmic drugs include procainamide, quinidine, propranolol, and phenytoin, which have different effects, either alone or in combination, and new drugs are needed for this purpose. Diisopropiramine is a new anti-arrhythmic drug that can be administered orally or intravenously. It is a “type I” drug that reduces sodium influx in cells, prolongs the duration of action potentials, and stops the pacemaker potential . This article reports the randomized comparison of the efficacy of lidocaine and diazepam on the prevention of ventricular arrhythmias. Methods: (1) Randomized trials: 26 patients had ≥4 chambers per minute