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目的探讨食管鳞状细胞癌(ESCC)中细胞外基质金属蛋白酶诱导因子(EMM- PRIN)蛋白的表达及临床意义。方法免疫组织化学染色法检测85例ESCC、18例癌旁不典型增生(AH)、38例癌旁“正常”鳞状上皮(NSEBC)和15例正常食管鳞状上皮(NSE)中EMMPRIN蛋白的表达。结果ESCC、AH、NSEBC和NSE中EMMPRIN蛋白的阳性率分别为80%(68/85)、39% (7/18)、66%(25/38)和20%(3/15)；ESCC中EMMPRIN蛋白阳性率高于非癌肿组织(P＜0．01,r =0．35)且阳性细胞分布区域不同；高、中度分化组ESCC中EMMPRIN蛋白阳性率高于低分化组(P＜0．01,r=0．29)；ESCC中EMMPRIN蛋白的表达与肿瘤浸润食管壁的深度、临床分期和淋巴结转移均无明显相关(P＞0．05)。结论EMMPRIN蛋白在ESCC组织的表达与在非癌肿组织的表达存在显著不同,且它与癌肿的组织分化程度有密切关系。
Objective To investigate the expression and clinical significance of extracellular matrix metalloproteinase inducer (EMM-PRIN) protein in esophageal squamous cell carcinoma (ESCC). Methods Immunohistochemical staining was used to detect EMMPRIN protein in 85 cases of ESCC, 18 cases of atypical hyperplasia (AH), 38 cases of normal squamous epithelium (NSEBC) adjacent to cancer, and 15 cases of normal esophageal squamous epithelium (NSE). expression. Results The positive rates of EMMPRIN protein in ESCC, AH, NSEBC and NSE were 80% (68/85), 39% (7/18), 66% (25/38) and 20% (3/15), respectively; The positive rate of EMMPRIN protein was higher than that of non-tumor tissue (P<0.01, r=0.35) and the positive cell distribution area was different. The positive rate of EMMPRIN protein in ESCC of high and moderately differentiated group was higher than that of poorly differentiated group (P< 0.01, r=0.29); The expression of EMMPRIN protein in ESCC was not significantly associated with tumor infiltration depth, clinical stage, and lymph node metastasis (P>0.05). Conclusion The expression of EMMPRIN protein in ESCC tissue is significantly different from that in non-cancerous tissue, and it is closely related to the degree of tissue differentiation of cancer.