神经管缺陷是指妊娠早期,胎儿的中枢神经系统发育分化不良所致的神经管畸形。神经管缺陷有无脑儿、脊柱裂、脑膨出。我国是世界上神经管畸形的高发区,也是造成流产、围产儿死亡以及终身残疾的主要原因之一。而叶酸是神经系统正常发育所必需的,研究证实,孕前及孕后3个月补充叶酸能够有效预防神经管畸形~([1-3])。自2010年1月永康市开展农村育龄妇女免费增补叶酸预防神经管缺陷项目以来,通过孕产妇产检门诊、婚检门诊及街道社区卫生服务中心人员,采用口头、书 Neural tube defects refer to neural tube defects caused by poorly differentiated development and differentiation of the central nervous system of the fetus in early pregnancy. Nerve duct defects with or without brain, spina bifida, encephalocele. Our country is the high incidence area of ​​neural tube deformity in the world and one of the main causes of abortion, perinatal death and permanent disability. Folic acid is necessary for the normal development of the nervous system, studies have shown that pre-pregnancy and 3 months after pregnancy folic acid supplementation can effectively prevent neural tube defects ~ ([1-3]). Since January 2010, Yongkang City, rural women of childbearing age to free up folic acid to prevent neural tube defects since the project, through maternal birth clinics, premarital clinics and street community health service center staff, using oral, book