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灯盏素是云南药物研究所从灯盏花(Erigeron breviscapus〔Van.〕H.-M.)中分离出的有效成分。药理研究表明:灯盏素有改善脑循环,增加脑血流量,增加营养性心肌血流量和肌肉血流量,抑制由ADP诱导的血小板聚集效应。1972年以来,灯盏花已用于临床治疗脑血管病及其后遗症——瘫痪,收到良好效果,特别对脑血栓形成疗效更好。为进一步探索灯盏素的活血化瘀作用,我们分别建立了家兔大脑微循环障碍,豚鼠软脑膜微循环障碍,及大鼠肠系膜微循环障碍模型,观察灯盏素对微循环障碍的作用。
Breviscapine is an active ingredient isolated from Erigeron breviscapus (Van. H.-M.) by the Yunnan Institute of Materia Medica. Pharmacological studies have shown that breviscapine can improve cerebral circulation, increase cerebral blood flow, increase trophic myocardial blood flow and muscle blood flow, and inhibit platelet aggregation induced by ADP. Since 1972, Erigeron breviscapus has been used for the clinical treatment of cerebrovascular diseases and its sequelae - warts, which have received good results and are particularly effective for cerebral thrombosis. To further explore the effects of breviscapine on blood circulation, we established rabbit brain microcirculation disorder, guinea pig pial microcirculation disorder, and rat mesenteric microcirculatory disturbance model to observe the effects of breviscapine on microcirculation.