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中毒性休克综合征(TSS)是一种与金葡菌感染相关的急性多系统疾病。它的临床特点为:突然发热、猩红热样皮疹、低血压、多个系统(消化系统、造血、肝、粘膜、肌肉、肺、肾和中枢神经系统)受累,最后有皮肤特别是手掌、足掌皮肤的脱屑。TSS的临床特点与重症链球菌性猩红热相似,有些症状又类似革兰氏阴性细菌败血症,因为链球菌性猩红热是由致热性外毒素(即红疹毒素)作用于敏感机体所致,因此设想TSS也是由相关毒素引起的。死于TSS患者的病理所见,也支持TSS由毒素引起的假设。
Toxic shock syndrome (TSS) is an acute multisystem disease associated with S. aureus infection. Its clinical features include sudden fever, scarlet fever-like rash, hypotension, multiple systems (digestive system, hematopoietic, liver, mucosa, muscle, lung, kidney and central nervous system) involved, and finally the skin, especially the palms, Skin desquamation. The clinical features of TSS are similar to those of severe streptococcal scarlet fever and some are similar to gram-negative bacterial sepsis because streptococcal scarlet fever is caused by a pyrogenic exotoxin (ie, rash toxin) on sensitive organisms TSS is also caused by related toxins. The pathology of patients who die from TSS also supports the hypothesis that TSS is caused by toxins.