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目的 探讨河北省张家口地区体检人群高尿酸血症患病情况及与心血管疾病危险因素的相关性,为高尿酸血症的预防提供科学依据.方法 选取2016年5月至2017年5月在张家口市某医院体检的人群为研究对象,检测其血尿酸、血压、体质指数(BMI)、空腹血糖、甘油三酯和总胆固醇;分别根据男女尿酸水平四分位数分组,统计并比较不同组间上述指标分布差异;根据各指标判定标准分层并比较男女人群高尿酸血症患病率及与各项指标间的关系.采用Spearman秩相关分析尿酸水平与各项指标的相关性,采用logistic回归进行多因素分析.结果 本研究人群高尿酸血症的患病率为23.50％ (4 060/17 273),男性患病率(31.22％)高于女性(12.04％),差异有统计学意义(P＜0.01);男女不同尿酸组年龄、BMI、收缩压、舒张压、空腹血糖、甘油三脂、总胆固醇的分布差异均有统计学意义(均P＜0.01).男性高尿酸血症患病率随年龄增长而下降(P＜0.01),女性则升高(P＜0.01).随着BMI指数的增加,男女高尿酸血症患病率均升高(均P＜0.01).高血压组和高血脂组人群高尿酸血症患病率均高于正常组,差异均有统计学意义(均P＜0.01).女性高空腹血糖组高尿酸血症患病率高于空腹血糖正常组(P＜0.01),而男性高空腹血糖组高尿酸血症患病率则低于空腹血糖正常组(P＜0.01).Spearman秩相关分析显示,总人群和女性尿酸水平与BMI、收缩压、舒张压、空腹血糖、甘油三脂和总胆固醇均呈正相关(均P＜0.01),而男性尿酸水平与空腹血糖呈负相关(r=-0.064,P＜0.01),与其他指标呈正相关(均P＜0.01).多因素logistic回归分析结果显示,超重或肥胖(OR=2.273)、高甘油三脂(OR=2.227)和高胆固醇(OR=1.121)为高尿酸血症的危险因素,而女性(OR=0.398)和高空腹血糖(OR=0.686)则是其保护因素.结论 张家口地区体检人群高尿酸血症患病率较高,其与超重或肥胖、高血脂等心血管疾病危险因素互为因果或者有协同效应.“,”Objective To investigate the prevalence of hyperuricemia and its correlation with cardiovascular risk factors in physical examination population in Zhangjiakou City,Hebei Province,so as to provide scientific evidence for prevention of hyperuricemia.Methods Individuals receiving physical examination were selected to participate in the survey from May 2016 to May 2017 in a hospital of Zhangjiakou.Their blood uric acid (BUA),blood pressure (BP),body mass index (BMI),fasting blood glucose (FBG),triglyceride (TG),and total cholesterol (TC) were tested.Based on the BUA level of the four percentile interval,the different distributions of these indexes between gender groups were analyzed.According to the standard of each index,the prevalence of hyperuricemia and its relationship with each index were compared.Spearman rauk correlation analysis was used to analyze the correlation of BUA level with various indexes.Factors associated with hyperuricemia were identified with multivariate logistic regression.Results The prevalence rate of hyperuricemia was 23.50％ (4 060/17 273);the prevalence in males (31.22％) was higher than that in females (12.04％) (P ＜ 0.01).The distributions of age,BMI,systolic BP,diastolic BP,FBG,TG,and TC in different BUA groups were statistically different in male and female groups (all P ＜ 0.01).The prevalence of hyperuricemia in males decreased with age (P ＜ 0.01),while increased in females with age (P ＜0.01).The prevalence of hyperuricemia in men and women increased as the BMI index increased (both P ＜ 0.01).The prevalence rates of hyperuricemia in hypertension group and hyperlipidemia group were higher than those in normal group (all P ＜0.01).The prevalence of hyperuricemia in female hyperglycemia group was higher than that in normal blood glucose group (P ＜0.01),while the prevalence in male group was lower than that in normal blood glucose group (P ＜0.01).The Spearman rank correlation analysis showed that levels of BUA were positively correlated with BMI,systolic BP and diastolic BP,FBG,TC and TC in the total population and the female groups (both P ＜ 0.01),while in males the level of BUA was negatively correlated with FBG (r =-0.064,P ＜ 0.01)and were positively correlated with other indicators (all P ＜ 0.01).Logistic regression analysis showed that obesity or overweight (OR =2.273),high TG (OR =2.227) and high TC (OR =1.121) were risk factors for hyperuricemia,while the female (OR =0.398) and high FBG (OR =0.686) were protective factors.Conclusion The prevalence of hyperuricemia was high in Zhangjiakou area,and had a causal or synergistic relationship with cardiovascular disease risk factors of overweight/obesity and hyperlipidemia.