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目的 探讨梅尼埃病 (Meniere′sdisease)患者与组织相容性白细胞抗原 (histocompatibilityleukocyteantigen ,HLA) II类基因DRB1等位基因的关联。方法 采用聚合酶链反应 序列特异性引物(polymerasechainreaction sequencespecificprimers,PCR SSP)技术。测试 6 0例梅尼埃病患者和 85名健康人对照。结果 患者组HLA DRB1 3+ 5 + 6 + 8基因组集团总数高于健康对照组 ,相对危险性为 1.99 ,P <0 .0 5 ,患者组HLA DRB1 0 9明显低于健康对照组 ,相对危险性为 0 .17,P <0 .0 1。结论 梅尼埃病患者HLA DRB1 0 9显著下降 ,提示HLA DRB1 0 9可能是梅尼埃病的保护性基因
Objective To investigate the association of histocompatibility leukocyte antigen (HLA) class II DRB1 alleles in patients with Meniere’s disease. Methods Polymerase chain reaction sequence specific primers (PCR SSP) were used. Sixty patients with Meniere’s disease and 85 healthy controls were tested. Results The total number of HLA DRB1 3+ 5 + 6 +8 genomes in patients was significantly higher than that in healthy controls (relative risk 1.99, P <0.05). HLA DRB1 0 9 was significantly lower in patients than in healthy controls Is 0 .17, P <0 .0 1. Conclusions HLA DRB1 0 9 in Meniere’s disease patients significantly decreased, suggesting that HLA DRB1 0 9 may be the protective gene of Meniere’s disease