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血管紧张素转化酶(ACE)抑制剂阻滞血管紧张素Ⅰ转化为Ⅱ,使循环中血管紧张素Ⅱ水平下降,是一类较为理想的血管扩张剂。在高血压和充血性心力衰竭(CHF) 治疗中的应用日益增多。作为抗高血压药时,降压效果显著,不影响血脂代谢;对于高血压伴有左室肥厚的患者,在血压控制后左室肥厚也隋之消退。CHF患者经ACE抑制剂治疗后,运动耐量增大;甲巯丙脯酸的优点是不损害脑循环,依纳普利则使室性心律失常明显减轻,猝死人数减少。
Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to angiotensin II, which decreases the level of angiotensin II in circulation and is an ideal type of vasodilator. There is increasing use in the treatment of hypertension and congestive heart failure (CHF). As an antihypertensive drug, the antihypertensive effect is significant, does not affect blood lipid metabolism; for hypertensive patients with left ventricular hypertrophy, left ventricular hypertrophy after blood pressure control Sui receded. CHF patients with ACE inhibitor therapy, exercise tolerance increased; captopril has the advantage of not damaging the cerebral circulation, while enalapril ventricular arrhythmia was significantly reduced, the number of sudden death decreased.