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本文综述在某些疾病和胃肠粘膜损伤中内源性前列腺素的作用。许多研究已证实,前列腺素,尤其是 E 型前列腺素在胃、十二指肠和其他各肠段粘膜经受各种坏死性刺激时具有细胞保护作用。另外,已证实某些非类固醇抗炎药物,如阿司匹林、消炎痛及异丁苯丙酸可引起胃粘膜的糜烂、溃疡和出血。这些药物引起粘膜损伤的机制被认为是由于抑制了内源性前列腺素的合成。相反,也有许多资料表明,在某些情况下,前列腺素可损伤胃粘膜,而非类固醇抗炎药却可对抗这种损害作用。前列腺素对食管的影响两个实验室提供的资料表明,前列腺素在食管炎的炎性变化中起作用。一项研究通过连续4天给猫灌入0.1N 的盐酸(1 ml/min,持续30min)而造成实验性食管炎,灌酸期间动
This article reviews the role of endogenous prostaglandins in certain diseases and gastrointestinal mucosal lesions. Many studies have shown that prostaglandins, especially E-prostaglandins, have cytoprotective effects when mucosa of the stomach, duodenum and other intestinal segments undergo various necrotizing stimuli. In addition, certain non-steroidal anti-inflammatory drugs such as aspirin, indomethacin and ibuprofen have been shown to erode, ulcerate, and blemish gastric mucosa. The mechanism by which these drugs cause mucosal damage is thought to be due to the inhibition of endogenous prostaglandin synthesis. On the contrary, there is also a lot of information that shows that in some cases, prostaglandins can damage the gastric mucosa, but non-steroidal anti-inflammatory drugs can fight this damage. Effects of prostaglandins on esophagus Two laboratories provide data suggesting that prostaglandins play a role in the inflammatory changes in esophagitis. One study resulted in experimental esophagitis by pouring 0.1N hydrochloric acid (1 ml / min for 30 min) into cats for 4 consecutive days,