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目的探讨中国人和澳大利亚人冠状动脉病变的差异。方法中国南京和澳大利亚悉尼3个中心同步注册入选临床可疑冠心病行冠状动脉造影病例6251例(黄种人3021例,白种人3230例),其中黄种人确诊冠心病患者2098例(占69.4%),白种人确诊冠心病患者2439例(占75.5%)。冠状动脉病变程度由病变部位、支数及病变 Gensini 总积分表示。结果 (1)两组冠状动脉病变主要累及血管均依次为左前降支、右冠状动脉、左回旋支和左主干。(2)黄种人和白种人男性三支病变分别为29.8%和34.0%,女性为15.8%和26.2%,男性左主干病变分别为9.6%和14.2%,女性为4.9%和11.6%,两组男性三支病变及左主干病变均高于女性,单支病变低于女性(P<0.01),双支病变不同性别问均无统计学差异(P>0.05)。(3)白种人三支病变及左主干病变为31.9%和13.5%,高于黄种人(分别为26.0%和8.3%,均P<0.01),单支病变低于黄种人(38.0%比44.7%,P<0.01),双支病变两组间差异无统计学意义(30.1%比29.3%,P>0.05)。Gensini 总积分随年龄增长而增加。40岁以上相同年龄段,白种人 Gensini 总积分均明显高于黄种人。结论冠状动脉病变随年龄增加而增加,男性冠状动脉病变严重程度较相同年龄段女性重。澳大利亚人冠心病患者冠状动脉病变严重程度均较中国人同性别重。提示同样程度冠状动脉粥样硬化,澳大利亚人比中国人早10余年。
Objective To investigate the difference of coronary artery disease between Chinese and Australian. Methods Three centers of Nanjing, China and Sydney, Australia were simultaneously enrolled in 6251 cases of coronary artery angiography (3021 yellow and 3230 white) in clinically suspected coronary heart disease. Among them, 2098 cases (69.4% , 2439 were diagnosed as coronary heart disease (75.5%) in Caucasian. Coronary artery lesions by the lesion, count and lesion Gensini total score said. Results (1) The main vascular lesions of the two groups were followed by left anterior descending branch, right coronary artery, left circumflex branch and left main trunk. (2) The three pathological changes of yellow and white male were 29.8% and 34.0%, respectively, 15.8% and 26.2% for women and 9.6% and 14.2% for male and 4.9% and 11.6% for women, respectively There were no significant differences between the two groups (P> 0.05). There were no significant differences between the two groups in gender and gender (P> 0.05). (3) The prevalence of three-vessel disease and left main trunk disease was 31.9% and 13.5% in whites compared with that of yellow race (26.0% and 8.3%, respectively, P <0.01) 44.7%, P <0.01). There was no significant difference between the two groups (30.1% vs 29.3%, P> 0.05). Gensini total score increases with age. The same age group over 40 years old, white Gensini total score was significantly higher than the yellow race. Conclusions Coronary artery disease increases with age. The severity of coronary lesions in males is heavier than that of females in the same age group. The severity of coronary lesions in Australian patients with coronary artery disease was heavier than that of Chinese. Tip the same degree of coronary atherosclerosis, Australians than Chinese as early as 10 years.