阿洛司琼(alosetron,商品名:Lotronex)片剂用于治疗妇女肠易激综合征(IBS)。该药自2000年2月9日被批准后,临床曾发现4例缺血性结肠炎,均为一过性、轻中度,停药后可逆转。 FDA于2000年6月,共收到7例致严重便秘的报告。6名患者因之住院,其中3人需要手术。同时,FDA还收到该药发生缺血性结肠炎的8份 Alosetron (Lotronex) tablets are used to treat irritable bowel syndrome (IBS) in women. The drug since February 9, 2000 was approved, the clinical had found that 4 cases of ischemic colitis, were transient, mild to moderate withdrawal after reversal. In June 2000, the FDA received a total of seven reports of severe constipation. Six patients were hospitalized, three of whom needed surgery. At the same time, the FDA also received eight copies of the drug for ischemic colitis