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目的探讨急性脑梗死患者缺血修饰蛋白(IMA)水平与脑梗死体积的关系。方法选择发病24h急性脑梗死患者116例,按照脑梗死体积分为4组,分别为0~5 cm~3组(35例);5~10 cm~3组(32例);10~15 cm~3组(28例);(15 cm~3组(21例);选取同期来本院体检的20例健康者为对照组。运用ACB比色法来测定血清IMA水平。结果 0~5 cm~3组、5~10 cm~3组、10~15 cm~3组、(15 cm~3组缺血修饰蛋白水平存在显著差异(P<0.01),急性脑梗死组血清IMA水平(除(15 cm~3组)与脑梗死体积呈线性正相关(<0.01)。结论急性性脑梗死患者血清IMA水平均高于对照组,IMA可以作为脑组织缺血敏感的非特异性生化指标,并且急性脑梗死患者血清IMA水平随脑梗死体积增加而增高。可能作为辅助手段预测病情进展。
Objective To investigate the relationship between the level of ischemic-modified protein (IMA) and the volume of cerebral infarction in patients with acute cerebral infarction. Methods One hundred and sixteen patients with acute cerebral infarction at 24 hours after onset were divided into 4 groups according to the volume of cerebral infarction: 0 ~ 5 cm ~ 3 (35 cases), 5 ~ 10 cm ~ 3 (32 cases), 10 ~ 15 cm (28 cases), 15 cases (15 cases), 3 cases (21 cases), and 20 cases of normal subjects who took physical examination in our hospital as the control group.Serum IMA levels were measured by ACB colorimetric method.Results 0 ~ 5 cm (P <0.01). Serum IMA levels in acute cerebral infarction group (except for 15 cm ~ 3) and infarct volume were positively correlated (P <0.01) .Conclusion Serum IMA levels in patients with acute cerebral infarction are higher than those in control group, IMA can be used as a nonspecific biochemical indicator of brain ischemia, and acute Serum IMA levels in patients with cerebral infarction increased with the increase of cerebral infarction volume may be used as an adjunct to predict the progression of the disease.