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单酰基甘油酯酶(MAGL)是丝氨酸水解酶超家族成员之一,与激素敏感性脂解酶一起将脂肪细胞和其他细胞内储存的三酰甘油分解为甘油和脂肪酸。此外,它还能够作用于内源性大麻素系统。但目前其生物学功能尚未完全了解。近年来部分学者开始关注其在癌症中的作用。本文通过对MAGL生理生化作用的描述,简要介绍其研究现状。1 MAGL的三维结构特征MAGL是MALL基因编码的蛋白,位于人类染色体3q21.3,相对分子质量为33×103,广泛存在于真核生物和哺
Monoacylglycerol esterases (MAGLs), members of the serine hydrolase superfamily, work with hormone-sensitive lipolytic enzymes to decompose triglycerides stored in fat cells and other cells into glycerol and fatty acids. In addition, it can act on the endocannabinoid system. However, its biological function is not yet fully understood. In recent years, some scholars began to pay attention to its role in cancer. This article describes the physiological and biochemical effects of MAGL and briefly introduces its current research. 1 Three-dimensional structure of MAGL MAGL is MALL gene encoding protein, located in the human chromosome 3q21.3, the relative molecular mass of 33 × 103, widely exists in eukaryotes and feeding