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通过羧甲基壳聚糖(CMCS)和聚天冬氨酸(PASP)溶液共混,CaCl2、乙二醛作双交联剂,合成了离子-共价交联pH敏感CMCS/PASP水凝胶。用红外光谱、扫描电镜分析了水凝胶的结构和形貌。研究了复合凝胶的溶胀性和pH响应性。结果表明,在磷酸缓冲溶液(PBS)中溶胀行为为非Fickian扩散,在NaCl中的溶胀行为为Fickian扩散。随CMCS含量变化,复合凝胶具有不同的pH响应性。CMCS/PASP体积比为4/4,CaCl2/乙二醛浓度为1%/2%时,具有双重pH响应性。
Anionic-covalent cross-linked pH-sensitive CMCS / PASP hydrogels were synthesized by blending carboxymethyl chitosan (CMCS) and polyaspartic acid (PASP) . The structure and morphology of the hydrogel were analyzed by infrared spectroscopy and scanning electron microscopy. The swelling and pH responsiveness of the composite gel were studied. The results showed that the swelling behavior was non-Fickian diffusion in phosphate buffered saline (PBS), and the swelling behavior in NaCl was Fickian diffusion. With the change of CMCS content, the composite gels have different pH responsiveness. CMC / PASP volume ratio of 4/4, CaCl2 / glyoxal concentration of 1% / 2%, with dual pH responsiveness.