论文部分内容阅读
Substance P(P物质,以下简称SP)是一种含有11个氨基酸的神经肽,主要分布于中枢神经系统和胃肠道内。P物质对多种生理过程有促进作用,除作为神经递质、神经调节和内分泌或旁分泌因子起作用外,它还可能参与其它生理过程。177Lu是一种具有优良核物理性质、可用于肿瘤放射性治疗的放射性核素。神经激肽受体NK-1在脑胶质瘤和胰腺癌中有高表达,放射性核素标记的
Substance P (substance P, hereinafter referred to as SP) is a neuropeptide containing 11 amino acids and is mainly distributed in the central nervous system and the gastrointestinal tract. Substance P promotes a variety of physiological processes, and it may also participate in other physiological processes in addition to its role as a neurotransmitter, neuromodulator, and endocrine or paracrine factor. 177Lu is a radionuclide with excellent nuclear physical properties that can be used for radiotherapy of tumors. Neurokinin receptor NK-1 is highly expressed in gliomas and pancreatic cancers, radionuclide labeled