曾有报道心得安能防止食道静脉曲张未破裂患者出血的危险。由于首次出血能致死,为此,我们进行了一项前瞻性、双盲试验以观察β受体阻滞剂是否也能防止首次出血。79例内窥镜证实有大片食道静脉曲张但从未出过血的肝硬化患者随机分成下列治疗组:安慰剂组,雷尼替丁组(300mg/天),萘多心安组 There was a reported risk of bleeding to prevent esophageal varices from rupturing. Because of the first lethality, we conducted a prospective, double-blind trial to see if beta blockers also prevent first-time bleeding. 79 patients with large esophageal varices confirmed by endoscopy but never exacerbated cirrhosis were randomized to the following treatment groups: placebo, ranitidine (300 mg / day), naproxen